Cardiovascular system
Select a class to view its mechanism of action and common medicines.
ACE inhibitors
General mechanism or description
Inhibit angiotensin-converting enzyme, reducing angiotensin II formation and bradykinin breakdown. This decreases vasoconstriction and aldosterone secretion.
Common medicines
Angiotensin II receptor blockers (ARBs)
General mechanism or description
Selectively block the angiotensin II AT1 receptor, reducing vasoconstriction and aldosterone release.
Common medicines
Beta blockers
General mechanism or description
Block beta-adrenergic receptors. Depending on the agent, they reduce heart rate, contractility, and renin release.
Common medicines
Calcium channel blockers
General mechanism or description
Reduce calcium entry through L-type channels. Dihydropyridines act mainly on vascular muscle; verapamil and diltiazem also slow cardiac conduction.
Common medicines
Diuretics
General mechanism or description
Increase renal sodium and water excretion through different nephron segments. The exact mechanism depends on the subclass.
Common medicines
Aldosterone antagonists
General mechanism or description
Block the mineralocorticoid receptor, decreasing sodium and water retention while conserving potassium.
Common medicines
Statins
General mechanism or description
Inhibit hepatic HMG-CoA reductase, reducing cholesterol synthesis and increasing hepatic LDL receptors.